Visiongain has published a new report entitled Single-use Bioprocessing Probes & Sensors Market Report 2024-2034: Forecasts by Workflow (Upstream, Downstream), by Type (Pressure Sensors, Temperature Sensors, Flow Meters and Sensors, pH Sensors, Oxygen Sensors, Conductivity Sensors, Others), by End-users (CMOs/CROs, In-house Manufacturers) AND Regional and Leading National Market Analysis PLUS Analysis of Leading Companies.

The global single-use bioprocessing probes and sensors market is estimated at US$3,291.0 million in 2024 and is projected to grow at a CAGR of 16.4% during the forecast period 2024-2034.

Stringent Regulatory Scenarios

Regulatory frameworks imposed by governing authorities play a critical role in shaping the macroeconomic environment, driving growth across various industries. These regulations create favourable conditions for industry expansion, particularly in sectors like bioprocessing, where adherence to standards ensures both product quality and operational safety. However, economies that thrive the most are those that limit government intervention in microeconomic affairs, allowing market forces to operate freely and fostering innovation and competition.

In today’s globalized world, increased commercial activity has resulted in enhanced export opportunities, which are best facilitated through free trade policies. Protectionist measures, such as excessively high tariffs, contradict the spirit of globalization and can stifle industry growth. For instance, the ongoing U.S.-China trade war is projected to have adverse effects on global markets, including the pressure sensor industry, as many companies maintain production units in China. Tariff-related disruptions have strained supply chains, threatening the growth trajectory of the sector.

Similarly, the single-use bioprocessing probes and sensors market, while benefiting from regulatory support, may face challenges from geopolitical tensions and trade barriers that disrupt global supply chains. Nevertheless, with a balanced approach that includes regulatory backing and market-driven strategies, industries such as bioprocessing can continue to prosper, overcoming the potential impact of external pressures.

How will this Report Benefit you?

Visiongain’s 230-page report provides 112 tables and 151 charts/graphs. Our new study is suitable for anyone requiring commercial, in-depth analyses for the single-use bioprocessing probes and sensors market, along with detailed segment analysis in the market. Our new study will help you evaluate the overall global and regional market for Single-use Bioprocessing Probes & Sensors. Get financial analysis of the overall market and different segments including type, process, upstream, downstream, and company size and capture higher market share. We believe that there are strong opportunities in this fast-growing single-use bioprocessing probes and sensors market. See how to use the existing and upcoming opportunities in this market to gain revenue benefits in the near future. Moreover, the report will help you to improve your strategic decision-making, allowing you to frame growth strategies, reinforce the analysis of other market players, and maximise the productivity of the company.

What are the Current Market Drivers?

Increasing Implementation of Single-use Technology (SUT) for Bioproduction

The advancement of bioprocess monitoring will be pivotal in addressing the future demands of bioprocess technology. Key challenges include the need to accelerate process development, reduce time to market, and ensure optimal utilization of cell factories. These goals align with the standards set by the Process Analytical Technology (PAT) initiative. However, microbial production processes remain insufficiently understood, largely due to the inherent complexity of cellular systems and the lack of robust sensing technologies. This gap is particularly evident in recombinant protein production, where there is a strong correlation between recombinant gene expression and host cell metabolism. To overcome these challenges, it is essential to explore the roles of various cellular compartments in biosynthetic pathways and to develop comprehensive process monitoring strategies that account for critical variables and their interconnections.

While progress has been made in developing innovative sensor systems, their application in bioprocessing is often limited. Constraints such as aseptic requirements, the need to measure multiple analytes, sensor drift, and low physiological relevance restrict the ability to conduct on-line and in-situ measurements. A thorough review of current bioprocess monitoring techniques reveals that only a few metabolic variables are closely linked to the chemical and physical parameters being studied. To mitigate this challenge, mathematical modelling is employed to uncover “hidden” information from on-line data, creating a connection to highly precise off-line biochemical data. These models allow for the continuous prediction of off-line data, which is otherwise obtained intermittently, thus enhancing the ability to detect critical process states in real time.

The complexity of this approach lies in the need to establish robust on-line and off-line datasets. In this context, online sensor systems are evaluated not only for their commercial availability but also for the adequacy of the corresponding off-line analytical assessment methods. By integrating advanced modelling techniques with innovative sensor technologies, bioprocess monitoring can be significantly enhanced, enabling better control and optimization of biotechnological production processes.

Rising Demand for Improved Bioprocess Monitoring

Over the past few decades, cell culture productivity for biologics has experienced tremendous growth, driven by technological advancements and process innovation. As the biologics market expands, research efforts are increasingly focused on improving product quality, consistency, and process uniformity. To achieve these goals, the effective implementation of Process Analytical Technology (PAT) has become essential, particularly within the framework of the Quality by Design (QbD) methodology, which emphasizes building quality into the manufacturing process.

While traditional bioprocess monitoring sensors have been in use for many years, recent innovations—especially in spectrometric sensors—are transforming their role in cell culture bioprocesses. The shift toward well-defined cell culture media and the growing emphasis on precise process control have opened the door for spectrometric techniques to gain widespread adoption in bioprocess monitoring. These methods enable more accurate measurement of critical process parameters, supporting tighter control over cell culture conditions.

The integration of advanced sensing technologies will be crucial for the real-time monitoring of cellular physiology, ensuring not only process consistency but also adherence to stringent product quality standards. As biologics manufacturing continues to evolve, the incorporation of these sophisticated monitoring tools will play a vital role in meeting industry demands for scalable, high-quality production processes, ultimately driving greater efficiency and reducing time to market.

Where are the Market Opportunities?

Industry 4.0 to Offer Lucrative Growth Prospects

Biomanufacturers are increasingly seeking state-of-the-art sensors designed for use in advanced, automated, and integrated processes such as closed-loop systems. Companies are looking for sensor devices that are non-invasive, flexible, and highly sensitive, adaptable for both single-use and multi-use applications. Some of the latest in-line sensors now offer real-time data transmission via wireless technologies like Bluetooth, enabling monitoring through devices such as laptops or tablets. Smart sensors are gaining prominence due to their ability to recalibrate automatically, often functioning seamlessly with sophisticated software systems. These innovations align with the broader trend toward digital manufacturing and the emergence of Industry 4.0, where automation, data exchange, and IoT (Internet of Things) are reshaping industries.

The Industrial Internet of Things (IIoT) allows for seamless connectivity between instruments, complex information systems, and process equipment, enabling real-time communication through the internet. IoT-enabled sensors integrated into smart devices can collect and relay data from equipment such as pumps, reactors, and lab systems. Additionally, these sensors can be connected either directly or indirectly to broader IoT networks, with an ideal configuration involving a wireless sensor network (WSN) embedded within an IoT framework for greater efficiency and monitoring.

As companies explore the potential of these emerging technologies, the life sciences sector is increasingly leveraging sensor technology for improved process control and operational efficiency. For instance, new sensor solutions are being developed to measure critical parameters like temperature and humidity, with applications extending across both GMP and non-GMP settings in modern facilities. These sensors are particularly valuable for troubleshooting in existing facilities equipped with Wi-Fi capabilities, offering cost-effective alternatives to centralized building or utility management systems. By extending Wi-Fi coverage to remote facilities, manufacturers can access high-quality data at a fraction of the cost, significantly enhancing operational capabilities.

In the biopharmaceutical industry, single-use sensors have gained widespread adoption, particularly in disposable bioreactors and various unit operations—from purification chromatography to final fill-finish processes. Leading companies are developing next-generation sensors capable of real-time measurement and process control for critical parameters such as pressure, temperature, conductivity, absorbance, and turbidity. This growing reliance on advanced sensor technologies is revolutionizing biomanufacturing, driving greater process control, efficiency, and scalability while aligning with the industry’s movement toward digital transformation.

Streamline Processing

Large stainless-steel tanks were the initial bioprocessing sensors and probe instruments, primarily because early producer cell lines yielded minimal output, necessitating larger culture volumes. Consequently, the use of expansive stainless-steel vessels became standard practice.

Historically, stainless-steel reactors dominated commercial biomanufacturing; however, there has been a significant shift as more manufacturers are now adopting single-use systems due to their cost-effectiveness and disposability.

In fact, single-use bioprocessing sensors and probes have surpassed stainless-steel installations in both volume and number among commercial producers. By employing intensified and continuous production processes, a 2000-L manufacturing train can achieve the same output of drug ingredients that previously required a 20,000-L facility. This evolution reflects the industry’s transition toward upgrading production cell lines and concentrating on niche, low-volume pharmaceuticals.

When weighing the options between stainless steel and plastic, efficiency concerns play a critical role in decision-making. The drive for streamlined processes and efficient transfers from research and development to manufacturing necessitates scalable systems that can adapt to varying production demands. This shift not only enhances operational flexibility but also aligns with the broader trend of optimizing biomanufacturing processes for improved productivity and cost-effectiveness.

Competitive Landscape

The major players operating in the single-use bioprocessing probes and sensors market are ABEC, Broadley-James Corporation, Avantor, Dover Corporation, ESI Ultrapure, Emerson Electric Co., Eppendorf AG, Equflow, Hamilton Company, High Purity New England, Inc. (a Getinge Company), METTLER TOLEDO, Parker-Hannifin Corporation, PreSens Precision Sensing GmbH, PendoTECH LLC, Sartorius AG, SONOTEC GmbH, and Thermo Fisher Scientific Inc. These major players operating in this market have adopted various strategies comprising M&A, investment in R&D, collaborations, partnerships, regional business expansion, and new product launch.

Recent Developments

• On 9th July 2024, in collaboration with Hamilton, Labor Berlin expanded the automation and standardization of its workflows in sample preparation.
• On 15th June 2024, Broadley-James announced its recent patent grant for its innovative single-use sensor line. Its SingleSense® single-use sensors enhance bioprocessing efficiency while ensuring precise monitoring and control – all with the convenience of single-use technology.

Notes for Editors

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